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RNU6-21P (RNA, U6 small nuclear 21, pseudogene) is a human pseudogene that is structurally similar to genes encoding U6 small nuclear RNA, an important non-coding RNA component of the spliceosomal machinery involved in pre-mRNA splicing[1][4][7]. However, as a pseudogene, RNU6-21P does not produce a functional RNA or protein product and is believed to be transcriptionally silent and biologically inactive. Many copies or pseudogenes of the U6 snRNA gene exist in the genome, likely reflecting the importance and high evolutionary conservation of the functional U6 snRNA, but these pseudogenes themselves have no established role in normal biology or disease processes[1][3][7].
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