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RNA, 5S ribosomal pseudogene 116 (RNA5SP116/RN5S116) is classified as a pseudogene in the human genome, specifically as an rRNA pseudogene derived from the 5S ribosomal RNA gene cluster[4][5][6]. Pseudogenes are segments of DNA that resemble functional genes but are typically non-functional due to mutations or lack of regulatory elements[2][5]. In this context, "5S ribosomal" refers to its origin from the 5S ribosomal RNA—an essential component of the large ribosomal subunit involved in protein synthesis. However, as a pseudogene, RNA5SP116 does not produce a functional rRNA molecule and is not involved in ribosomal assembly, protein synthesis, or any known cellular or biochemical process; it is instead a remnant of genomic evolution and serves no therapeutic, biomarker, or drug-target role[2][4][5][6]. There is no evidence linking it to human disease, drug interactions, or adverse effects.
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