RNA, 5S ribosomal pseudogene 197 (RNA5SP197)

RNA, 5S ribosomal pseudogene 197 (RNA5SP197) is a processed pseudogene found in Homo sapiens. It is annotated as a non-functional, intronless copy derived from the 5S ribosomal RNA gene, resulting from a retrotransposition event. Unlike the canonical functional 5S rRNA, which is an essential structural component of the large ribosomal subunit involved in protein synthesis, this pseudogene does not encode a functional RNA or protein and is not known to have an active biological or disease-associated role[4][2][8]. What is a pseudogene? Pseudogenes are genomic DNA sequences similar to known genes but are non-functional due to mutations, truncations, or lack of regulatory elements[2][8]. Processed pseudogenes like RNA5SP197 typically arise through reverse transcription and integration of RNA, leading to an intronless copy that generally accumulates mutations and lacks biological activity[8][2]. Biological and clinical relevance: Some pseudogenes have regulatory roles or may act as RNA molecules that impact gene expression (e.g., sponging microRNAs), but there is no evidence in public databases or primary literature suggesting RNA5SP197 has any such function or relevance as a biomarker or therapeutic target[4]. Summary: RNA5SP197 is a nonfunctional processed pseudogene of 5S rRNA, with no current evidence supporting any therapeutic, diagnostic, or molecular targeting role. Its only significance is as a genomic annotation, not a druggable or biologically functional gene[4][2][8].

Other names

RN5S197RNA, 5S ribosomal 197