RNA, 5S ribosomal pseudogene 312 (RNA5SP312)

RNA, 5S ribosomal pseudogene 312 (RNA5SP312) is a human processed pseudogene, derived from the 5S ribosomal RNA gene, and does not encode a functional protein[3][5]. It is transcribed as a non-coding RNA by RNA polymerase III, and clusters of these transcripts are upregulated in the liver and immune cells of patients with severe alcohol-associated hepatitis[2]. These pseudogene RNAs can interact with cytosolic nucleic acid sensors (such as RIG-I and ZBP1), triggering innate immune responses including type I interferon production and inflammatory cell death, thereby contributing to disease pathogenesis[2]. In general, processed pseudogenes, previously considered functionless, are now recognized to participate in diverse regulatory mechanisms, including acting as decoys (sponges) for microRNAs or RNA-binding proteins and modulating gene expression, and in disease can behave as DAMPs or participate in oncogenic/tumor-suppressive networks[7]. However, RNA5SP312 itself is not a therapeutic target, receptor, enzyme, or drug-interaction partner, but rather a genomic element with emerging importance in inflammatory diseases as a source of immunostimulatory RNA[2][3][5].

Other names

RN5S312RN5S313RNA5SP313RNA, 5S ribosomal 312RNA, 5S ribosomal 313RNA, 5S ribosomal pseudogene 313

Not a druggable target; no direct mechanism of action for drugs described. Its transcripts activate innate immunity through nucleic acid sensors (ZBP1, RIG-I), leading to interferon responses and potentially cell death[2].