RNA, 5S ribosomal pseudogene 387 (RNA5SP387)

RNA, 5S ribosomal pseudogene 387 (RNA5SP387) is a pseudogene, meaning it is a DNA sequence that closely resembles a functional gene—in this case, the gene encoding 5S ribosomal RNA—but contains mutations or sequence differences that prevent it from being transcribed or performing the biological functions of its parent gene[1][2][4][6]. 5S ribosomal RNA plays an essential structural and regulatory role in ribosomes, but pseudogenes like RNA5SP387 do not contribute to ribosome formation, regulatory signals, or protein synthesis because they are generally non-functional and not expressed[4][6]. Pseudogenes are not considered therapeutic targets such as receptors, enzymes, transporters, or transcription factors[1][2][4][6]. No known drugs interact with this target, and it does not have known biomarker or disease relevance. Pseudogenes can arise through several mechanisms (e.g., gene duplication or retrotransposition), but regardless of the type, they are generally marked by loss of function and accumulation of mutations[6]. The functional parent, 5S ribosomal RNA, is a conserved component of the ribosomal large subunit, critical in allosteric signaling and structural maintenance of the ribosome[3][5][7]. RNA5SP387 is specifically annotated in genetic databases as a pseudogene, and not as a protein-coding gene, receptor, enzyme, or any known drug target[1][2].

Other names

RN5S387RNA, 5S ribosomal 387RNA5SP387