RNA, 5S ribosomal pseudogene 406 (RNA5SP406)

RNA, 5S ribosomal pseudogene 406 (RNA5SP406) is a **non-coding RNA pseudogene** related to the canonical 5S ribosomal RNA gene. Pseudogenes of 5S rRNA may arise from duplication or retrotransposition of functional ribosomal genes, leading to sequences with loss-of-function mutations. These loci are usually transcriptionally inactive but can occasionally be transcribed and, in some cases, influence gene regulation at the RNA level through antisense pairing or interaction with epigenetic regulators[2]. However, there is no specific evidence that RNA5SP406 is transcribed or has any regulatory or clinical function. Unlike functional 5S rRNA genes, which encode a universally conserved component of the ribosome participating in the structural integrity and communication among ribosomal centers[1][3], this pseudogene is **not a protein-coding gene, receptor, enzyme, or transporter**. It is therefore not considered a therapeutic target, has no established disease relevance or associated drugs, and is mainly catalogued for genomic annotation and evolutionary studies[2][4]. Its main relevance is as a marker of evolutionary events and genome complexity.

Other names

RN5S406RNA5SP406RNA, 5S ribosomal 406