RNA, 5S ribosomal pseudogene 440 (RNA5SP440)

RNA, 5S ribosomal pseudogene 440 (RNA5SP440) is a **pseudogene** in the human genome annotated in gene databases (e.g., NCBI Gene 100873688, Ensembl ENSG00000276036). It is a non-coding DNA sequence that resembles the 5S ribosomal RNA gene but contains disabling mutations that prevent it from coding for functional RNA or protein. Unlike the canonical 5S rRNA, which is a structural and functional component of the ribosome, this pseudogene does not contribute to ribosome assembly or function. Most pseudogenes, including RNA5SP440, are biologically inert, though rare pseudogenes can participate in gene regulation under specific circumstances, for example by acting as competing endogenous RNAs (ceRNAs), producing antisense transcripts, or generating long non-coding RNAs; however, these roles have not been documented for RNA5SP440. This molecule is not considered a therapeutic target, nor is there evidence that it plays a role in disease or is modulated by drugs. Note: - The “440” in the name designates it as one of many nucleotide sequence variants or genomic copies of the 5S ribosomal RNA pseudogene family. - Functional 5S rRNA genes are essential for ribosome function, but pseudogenes like RNA5SP440 are not transcribed into active rRNA and do not participate in protein synthesis. - This entry is not suitable for inclusion in structured drug target databases mapping receptors, enzymes, or therapeutic targets.

Other names

RN5S440RNA, 5S ribosomal 440RNA5SP440