RNA, 7SL, cytoplasmic 435, pseudogene (RN7SL435P)

**RN7SL435P** is a human pseudogene corresponding to the 7SL RNA gene family, formally named "RNA, 7SL, cytoplasmic 435, pseudogene."[6] The 7SL RNA itself is the RNA component of the signal recognition particle (SRP), important for directing nascent secretory and membrane proteins to the endoplasmic reticulum during translation[1][5]. However, RN7SL435P is a **pseudogene**—a DNA sequence similar to a functional gene but rendered non-functional through mutation, truncation, or lack of expression[6][3][7][8]. Most 7SL RNA-like sequences dispersed in the human genome are such pseudogenes and do not give rise to functional RNA molecules, nor are they known to have direct biological, disease, or pharmacological roles; they result from reverse transcription and insertion events involving the original 7SL RNA gene, but lack expression of a functional product[3][7][8][6]. There is no evidence that RN7SL435P encodes a therapeutic target, participates in major biological pathways, or is relevant for biomarker or drug development. **Key points:** - RN7SL435P is a non-coding RNA pseudogene, not an active receptor, enzyme, or protein. - There are hundreds of such 7SL pseudogenes in the human genome, most of which are non-functional and not expressed[3][7][8]. - The canonical functional role belongs to the actual 7SL RNA gene and its product, not the pseudogenes[1][5]. - RN7SL435P is not currently associated with disease or therapeutic targeting. - No drugs, biomarkers, or safety concerns are relevant to this pseudogene.

Other names

7SL RNA pseudogeneRNA, 7SL, Cytoplasmic 435, PseudogeneRN7SL435P