RNA, U1 small nuclear 141, pseudogene (RNU1-141P)

RNA, U1 small nuclear 141, pseudogene (RNU1-141P) is a noncoding RNA pseudogene found in the human genome that resembles the U1 small nuclear RNA gene but includes sequence changes (mutations, deletions, or insertions) that disrupt functional expression[8][1][5][7]. The parental gene, U1 snRNA, plays an essential role in spliceosomal recognition of 5' splice sites during pre-mRNA splicing, and is a key component of the spliceosome[5][3]. In contrast, pseudogenes like RNU1-141P do not encode functional snRNA but may represent remnants of duplication or retrotransposition events. Recent research suggests some U1 snRNA pseudogenes may produce variant transcripts with regulatory roles in RNA processing or gene regulation, but these findings are limited to specific variants and not generalizable to RNU1-141P without direct experimental evidence[5][4]. Therefore, RNU1-141P is generally regarded as genomically silent, with no current therapeutic, diagnostic, or druggable relevance. It serves primarily as an annotation in genomic studies and gene family analyses, and is not a functional protein, enzyme, receptor, transporter, or transcription factor.

Other names

RNU1-141PRNA, U1 small nuclear 141, pseudogene