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Target intelligence / Profile preview
RNA, U1 small nuclear 27, pseudogene (RNU1-27P)
- Target
- RNU1-27P
- Molecular classification
- Other (Non-coding RNA pseudogene)
01
Overview
RNU1-27P is classified as a pseudogene related to the U1 small nuclear RNA family. It is annotated on chromosome 14 and does not encode protein-coding transcripts[5]. The U1 small nuclear RNA family is involved in the recognition of 5' splice sites during pre-mRNA splicing, but pseudogenes in this locus, including RNU1-27P, lack experimental evidence for functional RNA products or biological activity[1][5]. Some variant U1 snRNA genes (vU1), as opposed to canonical U1 snRNA genes, are located in complex, segmentally duplicated regions with highly similar sequences. Mutations in canonical U1 snRNA genes or in some functional variant loci (not including RNU1-27P) have been linked to cancer-associated splicing defects[2], but the specific role of RNU1-27P in disease or normal physiology is uncharacterized[2][5]. No drugs, biomarkers, or clinical safety considerations are attributed to this pseudogene.
- Other names
- RNU1-7RNU1-7PRNA, U1 small nuclear 7, pseudogeneRNU1-27P
02
Biological functions
Other (No direct/characterized biological function; related to small nuclear RNA gene cluster, potential regulatory involvement is undetermined)
03
Disease associations
Other (No direct role established; mutations in related U1 snRNA loci—not RNU1-27P specifically—have been associated with malignancy or splicing defects, but these genes' functionality is variable and genomic annotation is challenging)
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