RNA, U1 small nuclear 28, pseudogene (RNU1-28P)

RNU1-28P, or RNA, U1 small nuclear 28, pseudogene, is an annotated pseudogene related to the family of U1 snRNAs, which are essential RNA components of the spliceosome complex. While canonical U1 snRNA genes encode the 164-nucleotide RNA involved in defining the 5' splice site during mRNA splicing, RNU1-28P does not encode a functional transcript for use in classical splicing and is located at chromosome 14q13. Some U1 pseudogenes, historically considered non-functional, have been shown to be transcriptionally active and could have RNA-mediated regulatory roles, such as influencing pre-mRNA 3′ end processing in specific cell types. However, RNU1-28P itself is generally not regarded as a therapeutic target, receptor, enzyme, or transporter, and there is no evidence for disease linkage or drug interaction. It is primarily relevant as an example of persistent, expressed pseudogenes in the human genome, contributing to the complexity of non-coding RNA biology.

Other names

RNU1-28PRNU1-8RNU1-8PRNA, U1 small nuclear 8, pseudogene

Not applicable; no known therapeutic interactions