RNA, U2 small nuclear 1 (RNU2-1)

RNA, U2 small nuclear 1 (RNU2-1), commonly referred to as U2 or U2 snRNA, encodes a highly conserved small nuclear RNA that is an essential component of the major spliceosome in eukaryotic organisms[4][1]. U2 snRNA, assembled into U2 small nuclear ribonucleoprotein (snRNP), is responsible for recognizing the branch point sequence in introns and participates in the catalysis of pre-mRNA splicing by forming base pairs with U6 snRNA and interacting with protein complexes SF3a and SF3b[4][7][3]. This process is fundamental to the maturation of messenger RNA and the regulation of gene expression. U2 snRNAs exhibit extensive post-transcriptional modifications, including pseudouridylation and 2’-O-methylation[4]. Its loci are associated with specialized nuclear domains (coiled bodies), indicating a spatial organization of snRNA transcription and processing[5]. Disease relevance is primarily through recurrent mutations that have been observed in certain tumor types, but it is not considered a classical therapeutic target such as a receptor, enzyme, or transporter[2][1][4].

Other names

U2RNU2U2 snRNAU2 spliceosomal RNA

Not applicable; U2 snRNA is not directly drug-targeted.