RNA, U2 small nuclear 25, pseudogene (RNU2-25P)

RNU2-25P, or RNA, U2 small nuclear 25, pseudogene, is annotated as a **pseudogene** of the U2 small nuclear RNA family[2][3]. It does not code for a functional protein or mature snRNA and is not known to have independent biological activity. It is part of a family of pseudogenes derived from the U2 snRNA genes, which are components of the spliceosomal machinery. There is no evidence that RNU2-25P has a direct biological, regulatory, or disease-associated function, nor is it considered a receptor, enzyme, transporter, or bona fide drug target[3]. **Key points**: - **RNU2-25P** is a genomic sequence resembling U2 snRNA but is annotated as a pseudogene (i.e., it is not expressed as a functional product)[2][3]. - It lacks evidence of pathological or physiological roles, is not related to drug action, and is not a molecular target in a clinical or experimental context[3]. - This entry is likely misapplied if intended as a therapeutic or pharmacological target ("is_incorrect": true). **Additional context**: - While some other U2 snRNA loci—such as RNU2-2, which was formerly annotated as a pseudogene but subsequently shown to have functional consequences when mutated—have recently been found to be functional and disease-associated, **RNU2-25P is still classified as a non-functional pseudogene**[1][3]. References for further investigation: - GeneCards, BioGPS, and NCBI Gene entries consistently list RNU2-25P as a pseudogene without associated function, proteins, or clinical impact[2][3].

Other names

RNU2-25PRNA, U2 Small Nuclear 25, PseudogeneENSG00000222973 (Ensembl)106480208 (NCBI Gene)