RNA, U4 small nuclear 55, pseudogene (RNU4-55P)

RNU4-55P (RNA, U4 small nuclear 55, pseudogene) is a non-coding RNA pseudogene in the human genome that resembles the active genes encoding U4 small nuclear RNA, a critical spliceosomal RNA. Unlike functional snRNA genes, such as RNU4-2, which participate in mRNA splicing and are associated with neurodevelopmental disorders when mutated, RNU4-55P is a remnant or duplicate generated via retrotransposition and does not transcribe a functional RNA or protein product. Pseudogenes like RNU4-55P are prevalent in the human genome and may retain sequence similarity to functional snRNAs but lack biological activity or disease association[1][4][6]. RNU4-55P is not a receptor, enzyme, transporter, transcription factor, or any typical druggable target. It should not be confused with functional U4 snRNA genes (RNU4-2), which are important for spliceosome assembly and human neurodevelopmental disorders[5]. The inclusion of RNU4-55P as a therapeutic target or biomarker is incorrect and misleading[1][4].

Other names

RNU4-55PU4 snRNA pseudogene 55May be referred to generically as "U4 pseudogene" or "U4 small nuclear RNA pseudogene"

None applicable.