RNA, U4 small nuclear 84, pseudogene (RNU4-84P)

RNA, U4 small nuclear 84, pseudogene (RNU4-84P) is annotated as a pseudogene that shares sequence similarity with the functional U4 spliceosomal RNA genes, such as *RNU4-2*.[2] Pseudogenes do not code for functional proteins or RNA molecules, and there is no evidence that RNU4-84P produces a functional transcript or has a role in splicing, neurodevelopment, or disease.[2] It should not be confused with *RNU4-2*, whose variants are implicated in neurodevelopmental disorder syndromes and whose functional RNA is a critical part of the spliceosome in mRNA processing.[1][3][4][5] There is no evidence or reports of drugs or biomarker usage, molecular functions, or disease roles for RNU4-84P. Its annotation as a pseudogene indicates it does not function as a therapeutic target or as a molecular target in disease contexts. The primary reason this entry is "incorrect" is that it is not a bona fide target, but rather a non-functional pseudogene.[2] Ambiguity arises because *RNU4-84P* is a pseudogene, while function and disease relevance are established only for the functional gene *RNU4-2*.[1][3][4][5] If the intent was to ask about the U4 small nuclear RNA gene with known biological and disease relevance, *RNU4-2* should be used; this gene is relevant in neurodevelopmental diseases and encodes a non-coding RNA critical for the spliceosome.[1][3][4][5] No information supports any therapeutic or biological target status for RNU4-84P, and there is risk of confusion due to similar nomenclature.[2]

Other names

RNU4-84P