RNA, U6 small nuclear 1143, pseudogene (RNU6-1143P)

RNA, U6 small nuclear 1143, pseudogene" (RNU6-1143P) is a processed pseudogene derived from the U6 small nuclear RNA (snRNA) gene. U6 snRNA itself is an essential component of the major spliceosome complex, catalyzing intron removal during mRNA processing in eukaryotes[1][3]. However, pseudogenes like RNU6-1143P do not code for functional RNA molecules and are considered evolutionary remnants. These pseudogenes are thought to be generated during L1 (LINE-1) retrotransposition and have no assigned biological function, disease link, or therapeutic potential[5]. They serve as genomic markers for retrotransposition activity and genome evolution but are not considered drug targets, biomarkers, or candidates for therapeutic intervention[5]. In the human genome, U6 snRNA pseudogenes are common, resulting from retrotransposition events that duplicate snRNA genes without preserving their function[5]. While the parent U6 snRNA plays a crucial role in mRNA splicing[1][3], processed pseudogenes such as RNU6-1143P are transcriptionally inactive or rapidly degraded and do not contribute to spliceosomal function or pathology[5]. No evidence from current databases indicates a link between RNU6-1143P and any form of therapeutic targeting, disease association, or use as a biomarker. If you require information on functional U6 snRNA instead, those relate to canonical spliceosomal RNA, not to the pseudogene variants[1][3].

Other names

RNU6-1143PU6 snRNA pseudogene 1143RNA, U6 snRNA pseudogene 1143

None (not targeted by drugs; no related mechanism of action)