RNA, U6 small nuclear 118, pseudogene (RNU6-118P)

RNU6-118P (RNA, U6 small nuclear 118, pseudogene) is a genomic pseudogene derived from the U6 small nuclear RNA (snRNA) gene family. U6 snRNA is a core component of the spliceosome, responsible for catalyzing intron removal during eukaryotic pre-mRNA splicing[1][3]. However, as a "pseudogene," RNU6-118P represents a non-functional, transcriptionally inactive genomic remnant—lacking the capacity to produce a functional RNA or protein product[5]. Pseudogenes such as RNU6-118P arise via retrotransposition or gene duplication but acquire mutations that render them non-functional. They do not have known biological function, therapeutic relevance, or direct involvement in disease. RNU6-118P is not a receptor, drug target, or biomarker, and it is not associated with any drug interactions, mechanisms of action, or safety considerations[5]. Additional context: - The U6 snRNA gene family is highly conserved and essential for spliceosome activity, but RNU6-118P is a specifically annotated pseudogene, meaning it is one of many nonfunctional gene copies present in the human genome[3][5]. - Pseudogenes are often used as markers of genome dynamics rather than studied for direct cellular functions[5]. - RNU6-118P is neither a molecular target nor a functional component of biological pathways or disease mechanisms. Summary: RNU6-118P is a pseudogene, not a therapeutic target or functional molecule. Its listing as a "target" is incorrect; it is simply a non-coding, non-functional genomic sequence derived from the U6 small nuclear RNA gene[5].

Other names

RNU6-118PU6 small nuclear RNA pseudogene 118