RNA, U6 small nuclear 1235, pseudogene (RNU6-1235P)

RNU6-1235P is a **pseudogene** of the U6 small nuclear RNA gene family. U6 snRNA is a highly conserved, abundant non-coding RNA that functions as a core component of the spliceosome, catalyzing pre-mRNA splicing in the nucleus of eukaryotes[1][3]. However, RNU6-1235P is not a functional gene but a non-coding genomic sequence derived from U6 snRNA through retrotransposition or duplication events, typically mediated by LINE-1 elements[4][5]. Most U6 snRNA pseudogenes do not produce functional RNAs and have no known cellular role—they are considered "processed pseudogenes" and serve primarily as **genomic fossils/markers of retrotranspositional dynamics** inside the genome[4][5]. There are hundreds of U6 snRNA pseudogenes in the human genome, and they are **not considered drug targets, receptors, or enzymes**. They are not associated with known disease mechanisms or phenotypes and have no known therapeutic, diagnostic, or prognostic use[4][5]. Further clarification: The core gene, U6 snRNA, is a functional RNA essential for the spliceosome[1][3]. Many pseudogene copies of U6 exist across the genome, including RNU6-1235P, but these are not biologically active and are not targeted by drugs[4][5]. There is nothing inherently "incorrect" in the gene symbol or nomenclature, but the entity is **not a functional therapeutic target**—thus, it should be flagged as "not a target" for pharmacological or clinical interest[4][5]. If a therapeutic or biomarker relationship for a pseudogene is being proposed, that would be inconsistent with current biological understanding for the RNU6 pseudogene family. Summary: **RNU6-1235P is a pseudogene derived from the core spliceosomal U6 snRNA gene; it is not a receptor, not druggable, not associated with disease, and does not encode a functional product**[4][5].

Other names

RNU6-1235PRNA, U6 small nuclear 1235, pseudogene