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RNA, U6 small nuclear 1248, pseudogene (RNU6-1248P)
- Target
- RNU6-1248P
- Molecular classification
- Pseudogene, Small nuclear RNA (snRNA) pseudogene, Noncoding RNA pseudogene
01
Overview
RNA, U6 small nuclear 1248, pseudogene (RNU6-1248P) is a human genomic locus classified as a pseudogene—a noncoding, nonfunctional remnant derived from the U6 small nuclear RNA gene family[3][7][1][5]. U6 small nuclear RNAs (snRNAs) are critical components of the spliceosome, essential for pre-mRNA splicing in eukaryotic cells[8]. However, pseudogenes such as RNU6-1248P do not produce functional RNA products. These pseudogenes are commonly formed through retrotransposition events, particularly mediated by LINE-1 (L1) elements, and serve as evolutionary markers of genome rearrangement and the activity of mobile genetic elements[4]. RNU6-1248P and similar pseudogenes are abundant in the genome but have no known direct biological, therapeutic, or disease-modifying roles. They are not considered therapeutic drug targets, nor do they serve as clinically actionable biomarkers[3][7][1][4].
- Other names
- RNU6-1248PRNA, U6 Small Nuclear 1248, PseudogeneENSG00000212398 (Ensembl)NCBI Gene ID: 106480111HGNC: 48211GC01P223879 (former GeneCards ID)GC00U935828 (former GeneCards ID)
02
Mechanism of action
Not applicable
03
Biological functions
None (as a pseudogene, it does not encode a functional RNA or protein)
04
Disease associations
None known (pseudogenes are typically not implicated directly in disease as functional targets; occasionally may be markers for genome dynamics)
05
Safety considerations
None known
06
Interacting drugs
None
07
Biomarkers
None known
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