RNA, U6 small nuclear 1274, pseudogene (RNU6-1274P)

RNA, U6 small nuclear 1274, pseudogene (RNU6-1274P) is a non-protein-coding pseudogene derived from the U6 small nuclear RNA gene family, specifically designated as the 1274th annotated member in the human genome. U6 snRNAs are essential core components of the spliceosome, playing key roles in pre-mRNA splicing; however, as a pseudogene, RNU6-1274P is not functional—meaning it does not produce a functional U6 snRNA molecule. Pseudogenes like RNU6-1274P often arise from the retrotransposition or duplication of functional snRNA genes and accumulate mutations that prevent normal function. While some pseudogenes have been shown to act as regulatory RNAs (for example, by acting as decoys for microRNAs or affecting parental gene expression), there is no experimental evidence that RNU6-1274P has such roles. It is not a therapeutic or pharmacological target, does not encode for a protein or canonical RNA involved in cellular processes, and is not directly implicated in disease. The designation is correct and follows the established naming convention for pseudogenes of U6 small nuclear RNA [2][5].

Other names

RNU6-1274PU6 small nuclear RNA pseudogene 1274RNA, U6 snRNA pseudogene 1274