RNA, U6 small nuclear 133, pseudogene (RNU6-133P)

RNA, U6 small nuclear 133, pseudogene (RNU6-133P) is a processed pseudogene derived from the gene encoding U6 small nuclear RNA, an essential non-coding RNA involved in the splicing of pre-messenger RNA in eukaryotes[3][1][5]. U6 snRNA is a core component of the spliceosome, where it has a highly conserved catalytic role in intron removal from mRNA precursors[3][1]. However, RNU6-133P specifically refers to a **pseudogene** version; pseudogenes are genomic DNA sequences similar to normal genes but typically nonfunctional and do not encode proteins[4][5][2]. RNU6-133P does not have a known biological function, disease association, or targeting drugs because, as a pseudogene, it is not expressed as a functional RNA or protein product[4][5]. Its main importance is as a marker of retrotranspositional activity in the genome, reflecting the evolutionary history of U6 snRNA gene copies in humans and other vertebrates[5]. There is no evidence that RNU6-133P is a therapeutic or diagnostic target, nor is it associated with known safety or off-target concerns.

Other names

RNU6-133PU6 small nuclear RNA pseudogene 133