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RNU6-356P is a processed pseudogene related to the U6 small nuclear RNA gene family, which normally encodes a non-coding RNA component of the spliceosome, a complex involved in pre-mRNA splicing[3]. In humans and other vertebrates, many pseudogenes of U6 snRNA exist, reflecting its evolutionary importance[3]. Unlike its functional counterpart, U6 snRNA, RNU6-356P does not encode a protein and is generally considered to be non-functional. Some pseudogenes transcribe non-coding RNAs with potential regulatory roles (e.g., as decoys or antisense transcripts), but specific evidence for regulatory activity or disease impact of RNU6-356P is lacking[1][5]. Pseudogenes in general have been implicated in disease, especially cancer, through regulatory interactions, but most remain uncharacterized[1][4].
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