RNA, U6 small nuclear 405, pseudogene (RNU6-405P)

RNU6-405P encodes a **pseudogene** of the U6 small nuclear RNA (snRNA) family. Pseudogenes are genomic DNA sequences similar to normal genes but generally nonfunctional: they have lost protein-coding or RNA activity due to disabling mutations such as frameshifts or premature stop codons. The canonical U6 snRNA is a critical component of the spliceosomal machinery in eukaryotes, directly involved in pre-mRNA splicing as part of the U6 ribonucleoprotein. However, RNU6-405P does not produce functional snRNA and is annotated as nonfunctional by major genome databases. Pseudogenes can sometimes participate in regulatory functions, but specific activity for RNU6-405P has not been described. No disease association, biomarker role, or drug interaction is reported for RNU6-405P. In summary, **RNU6-405P is not a druggable target** and represents a genetically annotated pseudogene related to the highly conserved and functionally critical U6 snRNA involved in splicing in eukaryotic cells, but lacks functional activity as either an RNA molecule or a therapeutic target.

Other names

RNU6-405PRNA, U6 small nuclear 405, pseudogene

Not applicable; there are no drugs that target RNU6-405P, nor any established mechanism of action as a therapeutic target