RNA, U6 small nuclear 406, pseudogene (RNU6-406P)

RNU6-406P is a human pseudogene member of the U6 small nuclear RNA (snRNA) gene family[8][9]. U6 snRNAs are essential components of the spliceosome, required for pre-mRNA splicing in eukaryotes[1][3][5]. However, RNU6-406P is annotated as a "pseudogene," indicating that, unlike functional U6 snRNA genes, it does not produce a functional RNA product or contribute to spliceosomal activity. Pseudogenes such as RNU6-406P typically arise from duplication or retrotransposition events. They generally lack the regulatory sequences necessary for proper transcription and/or contain mutations preventing functional product formation[7][5].\n\nDespite the essential roles of canonical U6 snRNAs, the U6-derived pseudogenes—including RNU6-406P—are regarded as molecular relics with no known biological function, therapeutic targeting potential, or disease association. They may serve as markers of genome evolution, retrotranspositional history, or genomic instability but are not considered therapeutic targets[7][5][9].\n\nNo drugs, biomarkers, or clinical safety concerns are reported for RNU6-406P. There is no evidence to support any impact on disease, nor is it used for patient selection or monitoring.\n\nKey point: RNU6-406P is a non-functional, human small nuclear RNA pseudogene, not a receptor, enzyme, nor therapeutic target, and is primarily of genomic annotation interest[9][8][7].

Other names

RNU6-406PRNA, U6 small nuclear 406, pseudogene