RNA, U6 small nuclear 726, pseudogene (RNU6-726P)

RNU6-726P is a processed pseudogene derived from the U6 small nuclear RNA (snRNA), which in its functional form is a critical noncoding RNA involved in the spliceosome complex responsible for removing introns from pre-mRNA in the nucleus of eukaryotic cells[3][1]. Pseudogenes such as RNU6-726P arise through genomic duplication or retrotransposition events and typically contain mutations that prevent them from forming functional RNA or protein products[2][5]. While U6 snRNA is highly conserved and essential for catalytic activity in pre-mRNA splicing[1][3], pseudogenes like RNU6-726P are generally considered nonfunctional genetic elements. In rare cases, some pseudogenes may act as regulatory RNAs, but no specific regulatory function or disease link has been established for RNU6-726P[2]. Limitations & Notes: - There is *no evidence that RNU6-726P is a functional gene or therapeutic drug target*. - The presence of hundreds of U6 snRNA pseudogenes in the genome is typical, and they are usually considered "genomic fossils"[5]. - If structured data are needed for a functional target, the canonical gene is **U6 small nuclear RNA (RNU6)**, not its pseudogene variants. - Sources may refer to pseudogenes as part of regulatory networks, but specific information about RNU6-726P itself is lacking[2].

Other names

RNU6-726PRNA, U6 small nuclear 726, pseudogeneU6 snRNA pseudogene