RNA, U7 small nuclear 143 pseudogene (RNU7-143P)

**RNU7-143P** is classified as a *pseudogene* of the U7 small nuclear RNA (U7 snRNA) family. The functional U7 snRNA is a small nuclear RNA essential for the 3'-end processing of replication-dependent histone pre-mRNA as part of the U7 small nuclear ribonucleoprotein (snRNP) complex[1][3]. However, pseudogenes like RNU7-143P are genomic sequences that share high sequence similarity to the parent U7 snRNA gene but do not produce functional RNA due to mutations or truncations typical of reverse-transcribed pseudogenes[7]. While the bona fide U7 snRNA is required for histone pre-mRNA processing and indirectly influences chromatin biology, pseudogenes such as RNU7-143P are generally not transcribed or translated into functional molecules and lack known biological or disease-relevant functions in humans[4][7]. There are no known drugs targeting RNU7-143P, nor is it a biomarker, therapeutic target, or associated with safety concerns. **Key notes:** - **RNU7-143P** is not a functional RNA or protein, but a pseudogene, and not a therapeutic target[7]. - Related entries (like RNU7-1 or RNU7-14P) represent other pseudogenes or the functional gene, but RNU7-143P itself is characterized as a non-functional copy[7]. - There is nothing to suggest a disease or biomarker role for RNU7-143P, and current evidence suggests it does not encode a functional RNA or protein product. **Summary of issues:** - This is not a functional therapeutic target; it is a pseudogene, meaning it does not produce active RNA or protein and is not druggable. - It is likely being mistaken for the functional U7 small nuclear RNA gene (RNU7-1 or U7 snRNA), but RNU7-143P is non-functional[7]. - Many such pseudogenes exist for snRNAs, but these are generally unexpressed and lack known biological functions[4][7].

Other names

RNU7-143PRNA, U7 small nuclear 143 pseudogene