RNA, variant U1 small nuclear 23 (RNVU1-23)

This molecule is a variant form of U1 small nuclear RNA encoded by a pseudogene (class I U1 snRNA pseudogene). While classical U1 snRNA is a core element of the spliceosome that recognizes 5′ splice sites and initiates spliceosome assembly, variant U1 snRNAs—including those previously thought to arise from pseudogenes—have been shown to be transcribed, processed, and assembled into ribonucleoprotein complexes. Some variant U1 snRNAs can regulate expression of subsets of target genes through pre-mRNA processing, especially in developmentally controlled contexts. However, these variants are not established therapeutic targets or disease-related entities[3]. Key details: - Variant U1 snRNAs (vU1) are transcribed from loci historically annotated as pseudogenes. These "imperfect" copies can form unique ribonucleoprotein particles and function in the regulation of gene expression, especially in pre-mRNA processing[3]. - U1 snRNA variants may affect transcriptome integrity by modulating alternative polyadenylation and exon choice, but their individual functions (including RNVU1-23/RNU1-92P) are not well characterized, and they do not encode proteins[1][3]. - The molecular family is noncoding small nuclear RNA, not a receptor, enzyme, nor transporter. - Nomenclature is variable; the gene is frequently called by its database ID (e.g., RNU1-92P if corresponding), and variants are distinguished by number or annotation—RNVU1-23 is non-standard but might correspond to a cataloged pseudogene. Summary: RNA, variant U1 small nuclear 23 (RNVU1-23, RNU1-92P) is a pseudogene-expressed, noncoding RNA with functions in pre-mRNA processing and transcriptome regulation. It is not a recognized therapeutic target, and its nomenclature is non-standard and potentially ambiguous[3][2][5].

Other names

RNU1-92PRNA, U1 small nuclear 92, pseudogeneRNVU1-23 (variant U1 small nuclear RNA 23)

Null