RNA binding motif protein 11 (RBM11)

RNA binding motif protein 11 (RBM11) is a nuclear, tissue-specific RNA-binding protein that regulates alternative splicing primarily in the brain, cerebellum, testis, and, to a lesser extent, kidney[2][3][4]. It contains an amino-terminal RNA recognition motif (RRM) responsible for RNA binding, and a carboxyl-terminal region that allows nuclear localization and homodimerization[2][3]. RBM11 modulates selection of 5' splice sites by binding to specific RNA sequences (such as in BCL-X exon 2), antagonizing the activity of SR proteins like SRSF1, and is enriched in nuclear "splicing speckles"[2][3][4]. It affects differentiation events during neuronal and germ cell development and exhibits dynamic intra-nuclear localization in response to transcriptional activity or cellular stress[2][3]. Aberrant expression or function of RBM11 may contribute to disease, including cancer, by altering splicing events critical to cell fate[1][4].

Other names

Splicing regulator RBM11RNA-binding motif protein 11Putative RNA-binding protein 11RBM11 (most common short form)

Not established; since no drugs directly target RBM11, there are no confirmed mechanisms of action