RNA-binding motif protein 14 (RBM14)

RNA-binding motif protein 14 (RBM14) is a nuclear RNA-binding protein that possesses two RNA recognition motifs and multiple C-terminal hexapeptide repeats. It acts as a transcriptional coactivator and alternative splicing regulator, modulating nuclear hormone receptor activity and gene expression. RBM14 plays important roles in DNA damage response, especially in recruiting repair factors to double-strand break (DSB) sites and facilitating non-homologous end joining (NHEJ). It is also involved in the regulation of pre-mRNA splicing, mitotic spindle assembly, and the innate immune response via the cGAS-STING pathway. Dysregulation of RBM14 has been implicated in cancer progression (e.g., glioblastoma, osteosarcoma), cellular radioresistance, and certain neurodegenerative and ocular diseases[1][2][4][5][7].

Other names

RNA-binding protein 14SIPPSP2SYT-interacting proteinSYTIP1COAAParaspeckle protein 2RRM-containing coactivator activator/modulatorSynaptotagmin-interacting proteinCoactivator activatorTransmembrane protein 137RBM14-RBM4 (context: read-through transcript)

Not established for specific drugs as of the current evidence. Small molecules or oligonucleotides modifying RNA-binding or splicing may be conceptually possible, but no specific RBM14-targeted agents are described as of now.