RNA binding motif protein 15 (RBM15)

RNA binding motif protein 15 (RBM15) is an RNA-binding protein belonging to the SPEN family, characterized by three N-terminal RNA recognition motif (RRM) domains and a C-terminal SPOC domain. RBM15 is a key scaffold in the m^6A RNA methyltransferase "writer" complex (with METTL3, METTL14, WTAP), targeting specific mRNAs for methylation, and thereby influencing mRNA splicing, nuclear export, stability, and gene silencing—most notably, X-chromosome inactivation. It also regulates hematopoiesis, cell differentiation, and alternative splicing through complex protein-protein and protein-RNA interactions. RBM15 is implicated in oncogenesis: recurrently involved in chromosomal translocations (e.g., with MKL1 in acute megakaryocytic leukemia) and found overexpressed in several cancers, correlating with poor clinical outcomes. Experimental data show that RBM15 controls megakaryocyte development and hematopoietic stem cell differentiation, partly via regulation of proto-oncogenes such as c-Myc. The multifunctional nature of RBM15 makes it of interest both as a mechanistic biomolecule in pathophysiology and as a potential biomarker in oncology and hematology.

Other names

OTTOTT1One-twenty two protein 1RNA-binding motif protein 15one twenty-twoone-twenty-two protein 1putative RNA-binding protein 15RNA-binding protein 15

Direct administration of drugs targeting RBM15 is not established; it mainly acts as part of regulatory complexes (e.g., METTL3/METTL14/WTAP m^6A writer complex) and modifies mRNA or splicing, which may be indirectly modulated by experimental approaches targeting m^6A processes or splicing but there are no known direct pharmaceutical agents targeting RBM15