RNA binding motif protein 24 (RBM24)

RBM24 is a single-domain RNA binding protein containing an RNA Recognition Motif (RRM) at its N-terminus, which preferentially binds GU-rich sequences in target mRNAs. It is strongly and dynamically expressed in specific tissues, especially cardiac and skeletal muscle, and developmental sensory structures. RBM24 is essential for proper alternative splicing of muscle and heart genes, such as ACTN2, TTN, MYH6, and MYBPC3, and for cytoplasmic polyadenylation of lens mRNAs. It also regulates mRNA stability, including p21, p63, and SLC7A11, affecting cell cycle progression, apoptosis, and protection against ferroptosis. Mutations or deficiency in RBM24 are linked to congenital muscle, heart, and sensory disorders in animal models, and its downregulation is associated with certain human cancers. Although no direct drugs currently target RBM24, its molecular pathways present potential opportunities for therapeutic intervention.

Other names

RNA-binding protein 24RNPC6FLJ30829dJ259A10.1RNA-binding region-containing protein 6RNA-binding region (RNP1, RRM) containing 6

Modulation of mRNA splicing, stability, and translation; Protection against ferroptosis by stabilizing SLC7A11 mRNA; Interaction with translation initiation factor eIF4E to modulate p53 translation