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Target intelligence / Profile preview
RNA binding motif protein 46 (RBM46)
- Target
- RBM46
- Molecular classification
- RNA binding protein, Contains RNA recognition motif (RRM), Cancer/testis antigen, Other
01
Overview
RNA binding motif protein 46 (RBM46) is a germ cell–specific RNA-binding protein characterized by one or more RNA recognition motifs (RRMs)[2][4]. RBM46 is highly expressed in testis and is essential for gametogenesis, particularly in regulating the transition from mitosis to meiosis in germ cells by binding to specific sequences (GCCUAU/GUUCGA motifs) in the 3' untranslated regions (3'UTRs) of mRNAs encoding meiotic cohesin subunits such as SMC1B, SMC3, STAG3, and RAD21[1][3][5]. Loss of RBM46 function results in meiotic arrest and infertility, with its primary role being the post-transcriptional regulation of mRNAs critical for proper chromosome segregation and synaptonemal complex assembly during meiosis[3][5]. While RBM46 is classified as a cancer/testis antigen (CT68), there are no established therapeutics targeting this protein and its principal biological importance remains in reproductive cell differentiation and meiosis, not in established therapeutic targeting[2][5].
- Other names
- Probable RNA-binding protein 46CT68Cancer/testis antigen 68MGC27016Putative RNA-binding protein 46
02
Mechanism of action
Not applicable; no drugs reported to target RBM46
03
Biological functions
Regulation of mRNA translationRegulation of meiosisGametogenesisPost-transcriptional control (binding 3'UTRs of specific mRNAs)Chromosome segregationCell cycle (mitotic-to-meiotic transition)
04
Disease associations
Infertility (spermatogenic failure, impaired gametogenesis)[5]Possible biomarker in cancer (as a cancer/testis antigen, but currently no established direct oncogenic role)[2][5]Other (germ cell development disorders)
05
Safety considerations
None reported; knockout phenotypes in mice show infertility due to meiotic arrest but no evidence for on-target drug toxicity (as RBM46 is not currently a therapeutic target)
06
Biomarkers
Testicular/germ cell expression can serve as a biomarker for germ cell differentiation and function[1][3][4][5]Cancer/testis antigen 68, as detectable in certain cancers, but clinical utility as a biomarker is not yet established
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