RNA-binding motif protein 4B (RBM4B)

RNA-binding motif protein 4B (RBM4B) is a member of the RNA-binding protein family distinguished by its RNA recognition motifs and zinc finger domains, which facilitate its interaction with RNA molecules. It is mainly involved in the regulation of alternative splicing and translation of mRNAs, particularly in muscle cell differentiation, stress response, and circadian rhythm regulation. RBM4B is expressed in mammalian tissues, including the nervous system and pancreas, and may play a regulatory role in the alternative splicing of genes involved in glucose signaling and insulin sensitivity. Structurally, RBM4B consists of two N-terminal RNA recognition motifs (RRMs), a CCHC-type zinc finger, and a less conserved C-terminal domain important for nuclear localization and splicing function. Although described in cellular and disease processes, RBM4B is not considered a validated therapeutic target in current pharmacology, and no drugs are directed against it.

Other names

RBM4BRBM30MGC10871ZCCHC15RBM4LZCRB3BZCCHC21BRNA-binding motif protein 30RNA-binding protein 4BRNA-binding protein 30Zinc finger CCHC-type and RNA binding motif 3B

Not applicable (no approved drugs targeting RBM4B or mechanisms described)