RNA-binding motif protein X-linked (RBMX)

RNA-binding motif protein X-linked (RBMX) is an RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family that plays vital roles in the regulation of alternative splicing, pre-mRNA processing, gene transcription, and DNA repair[3][4][5]. RBMX is essential for genome stability, promoting homologous recombination and proper DNA damage response, and is required for correct sister chromatid cohesion and telomere maintenance[1][4]. In neuronal development, RBMX ensures accurate alternative splicing needed for normal brain function; mutations are causally linked to X-linked intellectual disability syndromes such as Gustavson and Shashi syndromes[1][2][3]. In various cancers, RBMX displays both tumor-suppressive and tumor-promoting effects, depending on context, by regulating splicing of genes controlling cell growth and apoptosis[4]. No drugs currently target RBMX directly, but its pivotal cellular functions make it a subject of biomedical interest for understanding genomic integrity, neurodevelopmental disorders, and cancer[1][2][3][4][5].

Other names

Heterogeneous nuclear ribonucleoprotein GhnRNP GRNA-binding motif protein, X chromosomeHNRPGRBMXP1RNMXHNRNPGGlycoprotein p43MRXS11MRXSGMRXSHRBMXRT

Not applicable; no therapeutic drugs are established for this target. Mechanisms described in the literature involve modulation of RNA splicing, DNA repair, protein–protein, and protein–RNA interactions