RNA-binding protein 28 (RBM28)

RNA-binding protein 28 (RBM28) is a specific nucleolar component of the spliceosomal small nuclear ribonucleoprotein complexes, uniquely associating with multiple snRNAs (U1, U2, U4, U5, U6) and potentially coordinating their transition through the nucleolus[1][5][3]. It responds to nucleolar stress and may move between cellular compartments to modulate the activity of proteins such as p53[9]. Mutations in RBM28 are associated with a rare syndrome characterized by alopecia, neurological defects, and endocrinopathies (ANE syndrome)[1][3]. There is no evidence that RBM28 is a direct target for current therapeutic drugs, nor are any biomarkers or mechanisms of drug action documented for this protein[3][9].

Other names

RNA binding motif protein 28FLJ10377NOP4ANES2810480G15Rik