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Target intelligence / Profile preview
Fused in Sarcoma (FUS)
- Target
- FUS
- Molecular classification
- RNA-binding protein, DNA-binding protein, Transcription factor, FET family
01
Overview
Fused in sarcoma (FUS), also known as RNA-binding protein FUS or translocated in liposarcoma (TLS), is a multifunctional DNA/RNA binding protein. It plays critical roles in various aspects of gene expression and genome maintenance, including transcription regulation, alternative splicing, mRNA transport, and DNA repair. FUS was first identified as part of an oncogenic fusion protein resulting from chromosomal translocation t(12;16)(q13;p11) found in human myxoid liposarcomas, and mutations/misregulation are implicated in several neurodegenerative diseases.
- Other names
- RNA-binding protein FUSTranslocated in liposarcomaTLShnRNP P2
02
Biological functions
Transcription regulationAlternative splicingmRNA transportDNA repairMicroRNA processing
03
Disease associations
Myxoid liposarcomaAmyotrophic Lateral Sclerosis (ALS)Frontotemporal Lobar Degeneration (FTLD)Neurodegenerative diseaseCancer
04
Safety considerations
Cytoplasmic aggregation/inclusion bodiesLoss of normal nuclear functionGain of toxic functionImpaired RNA metabolismDefective stress granule dynamics
05
Biomarkers
FUS fusion gene (in myxoid liposarcoma)FUS mutations (in ALS)
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