RNA-binding protein FXR1 (FXR1)

RNA-binding protein FXR1 is a member of the Fragile X-related (FXR) protein family that functions as a key regulator of RNA metabolism, including mRNA translation, stability, and miRNA biogenesis, primarily through its RNA-binding domains (KH and RGG motifs)[4][1]. It is essential for embryonic and postnatal development, with wide expression especially in the brain, muscle, and various other tissues[3][4]. FXR1 plays crucial roles in synaptic function, neuronal development, sleep and stress responses, and is implicated in cancer through the regulation of oncogenic mRNA stability and interaction with signaling molecules (e.g., PRKCI and ECT2 in lung cancer)[2][1]. FXR1 overexpression correlates with poor prognosis in several cancers and is under exploration as a novel therapeutic target and biomarker[2][4]. Loss of function or alterations in FXR1 expression contribute to neurodevelopmental and psychiatric disorders as well as malignancies[3][2]. Key attributes: - Acts at the post-transcriptional level to regulate gene expression via mRNA and miRNA networks[1][4]. - Functions in complexes involved in translation regulation, stress granule dynamics, and ribosomal assembly[1][4]. - Essential for cell survival and proliferation, notably in both brain and oncogenic contexts[2][3]. - Considered a promising diagnostic and potential therapeutic target in oncology[2].

Other names

FMR1 autosomal homolog 1hFXR1pCMYO9ACMYO9BFXR1PMYOPMILMYORIBFFMR1 autosomal protein-like protein 1RNA-binding protein FXR1