RNA-binding protein FXR2 (FXR2)

FXR2 (RNA-binding protein FXR2) is a member of the Fragile X protein family and is encoded by the FXR2 gene on chromosome 17. It is an RNA-binding protein that helps regulate neuronal mRNA translation and synaptic function, acting alongside proteins such as FMRP and FXR1[1][2][4][5]. FXR2 is a structural component of Fragile X granules in the brain, where it is essential for proper granule formation and neuronal development[1]. Its functions in the brain include regulating mRNA stability, particularly for targets such as Noggin mRNA in hippocampal neurogenesis, formation of synaptic structures, and modulation of neuronal translation processes[2]. FXR2 interacts in protein complexes with FMRP and FXR1 and binds RNA through KH domains and an RGG box, conferring selectivity for specific nucleic acid structures[3][4]. Although not a direct drug target, FXR2's dysregulation is associated with neurodevelopmental and psychiatric phenotypes in animal models, partially overlapping with functions of FMRP, the protein deficient in Fragile X syndrome[2][4]. Note: FXR2 is *not* a classical therapeutic target like a receptor, enzyme, or transporter, and there are no approved drugs or mechanisms of action reported for direct FXR2 modulation. The protein is best classified as an RNA-binding protein critical for neuronal mRNA regulation and plasticity.

Other names

FXR2PFMR1 autosomal homolog 2FMR1L2RNA-binding protein FXR2FXR2