RNA-binding protein MEX3B (MEX3B)

RNA-binding protein MEX3B is encoded by the MEX3B gene and functions as a post-transcriptional regulator modulating the stability and translation of specific mRNAs. It features two K homology (KH) RNA-binding domains and a RING finger domain, enabling it to bind RNA and participate in protein-protein interactions. MEX3B controls the expression of target mRNAs, including its own by an autoregulatory loop, and those involved in developmental signaling (e.g., FGF pathway), immune responses (as a TLR3 coreceptor), and immune evasion in cancer by destabilizing HLA-A mRNA. Dysregulation of MEX3B impacts neural development and cancer immunotherapy efficacy[1][2][5][7].

Other names

mex-3 RNA binding family member BRKHD3

For agents modulating MEX3B activity (experimental/biological), expected mechanisms would involve modification of MEX3B’s mRNA binding, destabilization of target mRNAs (such as HLA-A, TGFBR3), or altering its regulatory loops[1][5][6][7].