RNA-binding protein with multiple splicing (RBPMS)

RNA-binding protein with multiple splicing (RBPMS) is a member of the RNA recognition motif (RRM) family of RNA-binding proteins, characterized by a single RRM at the N-terminus[1][4]. RBPMS is primarily known as a post-transcriptional regulator that mediates alternative splicing by binding to specific RNA sequence motifs (tandem CAC trinucleotide repeats) near regulated exons, acting as both a splicing activator and repressor depending on its target[1][2][3][6]. It plays a key role in the development and function of cardiac and smooth muscle cells, regulating the inclusion of exons in structural and contractile genes critical for heart and vascular function[3][6]. RBPMS interacts with core spliceosome components, other splicing factors, and transcription regulators, and may also influence mRNA translation and localization[3][5]. Dysregulation of RBPMS has been linked to congenital heart defects, dilated cardiomyopathy, and possibly to some cancers[1][3][6]. RBPMS is highly specific as a marker for retinal ganglion cells in the retina, making it a valuable tool in neuroscience research[4].

Other names

HERMESheart and RRM expressed sequenceRNA binding protein, mRNA processing factorRBP-MSHermes