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RNA G-quadruplexes in mRNA Untranslated Regions (rG4s in UTRs)
- Target
- rG4s in UTRs
- Molecular classification
- RNA secondary structure, Non-coding RNA element
01
Overview
RNA G-quadruplexes (rG4s) are non-canonical, four-stranded secondary structures formed by guanine-rich sequences in the untranslated regions (UTRs) of mRNA. They play significant roles in post-transcriptional regulation of gene expression by influencing translation initiation, mRNA localization, and interaction with RNA-binding proteins. Because small molecules can stabilize or destabilize these structures, rG4 elements represent promising targets for therapeutic intervention aimed at modulating specific protein outputs without altering DNA sequence itself.
- Other names
- RNA G-quadruplexes in 5' UTRRNA G-quadruplexes in 3' UTRrG4 structures in mRNAG-quadruplexes in mRNA UTRs
02
Mechanism of action
Modulation of translation by stabilizing or destabilizing rG4 structures in mRNA UTRs
03
Biological functions
Translational regulationmRNA localizationRegulation of gene expressionPost-transcriptional regulation
04
Disease associations
CancerNeurodegenerative diseaseGenetic disorders
05
Safety considerations
Off-target effects of rG4-modulating small moleculesUnintended consequences of altering mRNA localization or translation of multiple genes
06
Interacting drugs
Small molecules that stabilize rG4s
1 more in the full profile.
07
Biomarkers
rG4 structure presence/abundance in UTRs of specific genes
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