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DNA-directed RNA Polymerase Subunit Beta
- Molecular classification
- Enzyme, Polymerase, Transcription factor (component)
01
Overview
DNA-directed RNA polymerase subunit beta is a core component of the multi-subunit DNA-dependent RNA polymerase enzyme complex, which catalyzes the transcription of DNA into RNA. This process uses the four ribonucleoside triphosphates (ATP, GTP, CTP, UTP) as substrates to synthesize an RNA strand complementary to a DNA template. It is a key target for antimicrobial drugs such as rifampicin.
- Other names
- rpoBRNA polymerase beta subunit
02
Mechanism of action
Inhibition of bacterial transcription by binding near the active site of the RNA polymerase beta subunit.
03
Biological functions
TranscriptionRNA synthesisTemplate-dependent nucleotide polymerization
04
Disease associations
Infection
05
Safety considerations
Development of antibiotic resistance
06
Interacting drugs
Rifampicin
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