Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
RNA Polymerase I (Pol I)
- Target
- Pol I
- Molecular classification
- Enzyme, RNA Polymerase
01
Overview
RNA polymerase I (Pol I) is a multi-subunit enzyme found in eukaryotic cells that is responsible for the transcription of ribosomal RNA (rRNA), specifically the precursor rRNA that is processed into 18S, 5.8S, and 28S rRNAs in higher eukaryotes (or 25S in yeast). This process occurs within the nucleolus and represents a critical step in ribosome biogenesis and cell growth regulation. Pol I exclusively transcribes ribosomal DNA (rDNA) to produce a single large pre-rRNA transcript, and does not transcribe the gene for 5S rRNA. Synthesis of rRNA by Pol I sets the pace for ribosome production—a key determinant of cellular protein synthesis capacity. Dysregulation can contribute to diseases like cancer due to unchecked growth signaling pathways involving increased ribosome biogenesis.
02
Mechanism of action
Inhibition of rRNA transcription
03
Biological functions
TranscriptionRibosome biogenesisrRNA synthesisCell growth regulation
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects on other RNA polymerasesDisruption of ribosome biogenesisCell proliferation dysregulation
Beyond the preview
Go deeper on RNA Polymerase I (Pol I).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on RNA Polymerase I (Pol I).