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Target intelligence / Profile preview
RNA polymerase II-associated protein 1 (RPAP1)
- Target
- RPAP1
- Molecular classification
- Other (Accessory protein associated with RNA polymerase II complex), Possible ARM (Armadillo) repeat protein superfamily (based on sequence alignment)
01
Overview
RNA polymerase II-associated protein 1 (RPAP1) is a large, evolutionarily conserved protein identified as a component that physically associates with the RNA polymerase II (RNAPII) complex in human cells[3][4]. It does not possess a clearly defined catalytic activity or domain but may play a role in recruiting or stabilizing RNAPII at chromatin, thereby impacting transcriptional regulation. RPAP1 shares homology with essential proteins in yeast required for cell viability and gene expression, suggesting a conserved but possibly non-catalytic role in transcriptional processes. RPAP1 may also belong to the Armadillo (ARM) repeat protein superfamily, although definitive structural motifs were not confirmed. Its precise functional contributions, particularly in human cells, remain under investigation[3][4].
- Other names
- KIAA1403DKFZP727M111MGC858FLJ12732RNA polymerase II associated protein 1
02
Biological functions
Transcription regulation (Participates in the process of transcription by associating with RNA polymerase II and being required for normal gene expression)Chromatin recruitment (May aid in recruiting RNA polymerase II to chromatin)
03
Disease associations
Other (No direct disease associations have been well established for RPAP1. However, since RNA polymerase II dysfunction is implicated in various diseases, accessory proteins like RPAP1 may have indirect involvement)
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