RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like protein 1 (SSU72L1)

SSU72-like 1 (SSU72L1) is listed in gene and protein databases with names and aliases suggesting functional similarity to SSU72, a known CTD phosphatase critical for RNA polymerase II transcription regulation in eukaryotes[1][3][4][5]. However, SSU72L1 is annotated as a *pseudogene* (not a functional gene product) in major resources. SSU72 is a well-characterized enzyme that dephosphorylates the C-terminal domain (CTD) of RNA polymerase II, regulating the transcription cycle, especially at initiation and termination[1][2][3][4][5]. There is no evidence in available databases or literature that SSU72L1 encodes a functional protein, or that it acts as a therapeutic target; all phosphatase activity and biological roles described pertain to SSU72, not the SSU72L1 pseudogene. Therefore, SSU72L1 should not be considered a valid molecular target. Explanation of interpretation: Based on your query and available authoritative data, "SSU72-like 1" (SSU72L1) is a likely *pseudogene* (non-functional gene homolog), also described as "SSU72 RNA polymerase II CTD phosphatase homolog pseudogene 7".[4][5] All documented molecular functions, involvement in RNA polymerase II CTD dephosphorylation, and transcription regulation refer to the parent enzyme SSU72, not to SSU72L1. There is no evidence for druggability, functional protein product, or disease association for SSU72L1. If information about the functional SSU72 phosphatase (not SSU72L1) is needed, please clarify; detailed data about SSU72 (which is a known therapeutic target and important enzyme) is available in the cited sources[1][2][3][4][5].

Other names

SSU72 like 1SSU72L1CTD phosphatase SSU72L1SSU72P7SSU72 RNA polymerase II CTD phosphatase homolog pseudogene 7SSU72 pseudogene 7