RNA polymerase II subunit A C-terminal domain phosphatase Ssu72-like protein 6 (SSU72L6)

The so-called "SSU72 like 6" (SSU72L6), also referred to as "SSU72 pseudogene 8" and other similar names, appears to represent a **pseudogene** or non-functional homolog related to the genuine *Ssu72* phosphatase, which is an enzyme crucial for regulating transcription by dephosphorylating the C-terminal domain (CTD) of RNA polymerase II[2][3][5]. The well-characterized Ssu72 is an essential phosphatase involved in key steps of the eukaryotic transcription cycle, mRNA processing, and possibly phosphate homeostasis; it participates directly in dephosphorylating CTD serine-5 and sometimes serine-7 residues[1][2][3][5]. However, **no evidence in current biomedical or pharmacological literature supports SSU72L6 as an active enzyme, receptor, or therapeutic target**; rather, its gene product is most likely an unprocessed pseudogene without any demonstrated function, biological activity, or disease relevance. **Key clarification:** The biologically active phosphatase is named "RNA polymerase II subunit A C-terminal domain phosphatase Ssu72" (abbreviated as SSU72), not SSU72L6. Based on current scientific knowledge, SSU72L6 is *not* a therapeutic target, and no interacting drugs, roles in human diseases, or clinical biomarkers are established for it. If your focus is the functionally validated transcriptional phosphatase, refer to "RNA polymerase II subunit A C-terminal domain phosphatase Ssu72" (SSU72); SSU72L6 designates a likely non-coding, non-functional pseudogene.

Other names

SSU72 like 6SSU72L6CTD phosphatase SSU72L6SSU72P8RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like protein 6SSU72 pseudogene 8SSU72 RNA polymerase II CTD phosphatase homolog pseudogene 8