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Target intelligence / Profile preview
RNA polymerase II subunit H (POLR2H)
- Target
- POLR2H
- Molecular classification
- Enzyme, Transcription factor complex subunit (RNA polymerase subunit)
01
Overview
RNA polymerase II subunit H (RPB8/POLR2H) is a small, evolutionarily conserved protein that forms part of the core structure of the eukaryotic RNA polymerase II, and is also present in polymerases I and III. It interacts with multiple other subunits (including RPB1, RPB2, RPB3, and RPB5) and contributes to the structural integrity and assembly of the transcription machinery, which is responsible for synthesizing messenger RNA (mRNA) and several small nuclear RNAs in the nucleus.
- Other names
- RPB8POLR2HRNA polymerase II subunit RPB8RNA polymerase I subunit HRNA polymerase III subunit H
02
Mechanism of action
Drugs targeting the polymerase complex act by inhibiting RNA synthesis, blocking transcription of genes necessary for cell survival or viral replication
03
Biological functions
Transcription of DNA to RNAComponent of RNA polymerase complexRegulation of gene expression (via complex assembly—which is crucial for accurate mRNA synthesis)
04
Disease associations
No direct disease association for subunit H. However, dysfunction or mutation in the RNA polymerase II complex is implicated in: CancerNeurodegenerative diseasesHIV latency
05
Safety considerations
Direct inhibition of RNA polymerase II (not subunit H specifically) leads to broad toxicity due to loss of mRNA synthesis in all cells, explaining why clinical application is limited and challenging
06
Interacting drugs
No direct drugs target subunit H. Some anti-cancer drugs and antibiotics (e.g., α-amanitin) target the activity of RNA polymerase II as a whole
07
Biomarkers
Typically, expression/activity of the RNA polymerase II complex (not subunit H specifically) may serve as a biomarker for cell proliferation in cancer or for monitoring transcriptional activity
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