RNA Processing (None)

RNA processing refers to the series of molecular events that convert a primary RNA transcript (pre-RNA) into a mature, functional RNA molecule. This process is essential in eukaryotic cells and involves several modifications that prepare messenger RNAs (mRNAs), ribosomal RNAs (rRNAs), and transfer RNAs (tRNAs) for their respective roles in protein synthesis and other cellular functions. Key steps include capping, splicing, and polyadenylation for mRNA, as well as cleavage, methylation, and base modifications for rRNA and tRNA. RNA processing is a targetable process for therapeutic intervention.

Modulation of gene expression post-transcriptionally by targeting specific steps or factors involved in RNA processing. Mechanisms vary depending on the specific drug type (e.g., ASOs binding to target RNA, siRNAs inducing RNA degradation, small molecules inhibiting RNA processing enzymes).