RNA recognition motif-containing protein (RRM-domain RBP)

RNA recognition motif (RRM)-containing proteins constitute the largest and most diverse family of RNA-binding proteins in eukaryotes, characterized by a conserved domain of approximately 80-90 amino acids (Maris et al., 2005, FEBS J). These proteins are central regulators of post-transcriptional gene expression, governing processes such as pre-mRNA splicing, mRNA stability, transport, and translation (Clery et al., 2008, Curr Opin Struct Biol). In many diseases, RRM proteins are either mutated, mislocalized, or overexpressed, leading to proteotoxicity or aberrant gene expression (Lukong et al., 2008, Bioessays). For instance, the RRM-containing proteins TDP-43 and FUS are hallmark components of protein aggregates in neurodegenerative disorders like Amyotrophic Lateral Sclerosis (ALS) (Neelamraju et al., 2015, RNA Biol). In cancer, proteins like HuR (ELAVL1) stabilize mRNAs encoding pro-survival and pro-proliferative factors, contributing to tumor progression (Wu et al., 2015, Nat Rev Cancer). Therapeutic strategies targeting these proteins include small molecules designed to disrupt the RRM-RNA interface and antisense oligonucleotides aimed at correcting splicing defects or reducing toxic protein levels.

Other names

RNA recognition motif proteinsRNP-domain proteinsRNA-binding domain proteinsRRM proteinsRibonucleoprotein domain proteins

Inhibition of RNA-protein interaction, modulation of alternative splicing, and regulation of mRNA stability or translation.