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RNA Splicing Machinery (Spliceosome)
- Target
- Spliceosome
- Molecular classification
- Ribonucleoprotein complex, snRNP, RNA-binding protein
01
Overview
The RNA splicing machinery, or spliceosome, is a large ribonucleoprotein complex responsible for removing introns from pre-mRNA and ligating exons. It consists of five snRNPs (U1, U2, U4, U5, U6) and over 300 associated proteins. It plays a crucial role in gene expression and proteomic diversity through alternative splicing. Dysregulation of splicing is implicated in various diseases, including cancer.
- Other names
- Spliceosome complexmRNA splicing machineryNuclear spliceosome
02
Mechanism of action
Modulation of RNA splicing
03
Biological functions
RNA splicingGene expression regulationmRNA processingAlternative splicing
04
Disease associations
CancerGenetic disordersNeurodegenerative diseases
05
Safety considerations
Off-target effects on splicingPotential for unintended isoform switchingComplexity of the splicing code
06
Biomarkers
Aberrant splice variantsExpression levels of splicing factors
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